2019 Charity Recipient

The Translational Genomics Research Institute (TGen), an affiliate of City of Hope, is a Phoenix-based nonprofit biomedical research institute dedicated to unraveling the genetic components of cancer, diabetes, neurological disorders, infectious diseases and rare childhood disorders. TGen’s expertise and innovative use of cutting-edge technology allows scientists and clinicians to understand the genetic drivers of disease, detect disease earlier, identify more effective therapies and rapidly move scientific discoveries into the clinic. 

Ovarian Cancer Research at TGen

Ovarian cancer is now the 5th most common cancer in women. It also is one of the more lethal types of cancer, with a 5-year survival of less than 50%. This is due in part to the lack of clinically valid screening tools, combined with an absence of definitive symptoms in the early stages of the disease. This means that ovarian cancer often goes undetected until it has progressed to other parts of the body.

In recent years, TGen has led groundbreaking national and international advances in the discovery of the genetic cause of a particularly lethal form of ovarian cancer called small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).  Thanks to generous donors like Trends Charitable Fund (TCF), TGen is moving promising new therapies into clinical trials.

More work remains to be done to prevent ovarian cancer and detect the disease in its early stages, when it may be easier to treat. Support from TCF and other partners allow TGen to move quickly and, using the power of the human genome, capitalize on emerging opportunities; moving the needle to advance life-saving research. 
 

​TGen’s Center for Rare Childhood Disorders

Rare and undiagnosed disorders are estimated to affect 1 in every 10 Americans. Nearly half involve children, 30% of whom will not live to see their 5th birthday. Many of these children and their families endure years of trial-and-error testing with inconclusive results as they search for merely a diagnosis, let along a cure. This agonizing journey takes a tremendous psychological and emotional toll on these families. Many face financial hardships as they spend their resources in pursuit of an answer. 

TGen uses advanced genomic testing to give hope and answers to these families. Since 2012, C4RCD has served more than 600 patients with a diagnosis rate of 40%, nearly twice the national average.

And we are committed to doing more.

Nearly two-thirds of TGen’s pediatric patients do not have insurance to cover genomic testing. Thanks to the generous support from partners including Trends Charitable Fund, TGen is able to provide testing at no cost to many of these families. This year, gifts to C4RCD are matched dollar-for-dollar through the Dorrance Challenge.
 

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A&A COTTAGES, INC.
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ARIZONA HELPING HANDS
ARIZONA’S CHILDREN ASSOCIATION
ASSISTANCE LEAGUE OF PHOENIX
BOYS AND GIRLS CLUB OF METROPOLITAN PHOENIX
CHICANOS POR LA CAUSA
CORTNEY'S PLACE
CRISIS NURSERY
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DESERT MISSION
DESERT MISSION, INC.
DUETS
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FREE ARTS FOR ABUSED CHILDREN OF ARIZONA
FRESH START WOMEN’S FOUNDATION
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GREATER PHOENIX YOUTH AT RISK FOUNDATION, INC.
HOMELESS YOUTH CONNECTION
HOMEWARD BOUND
ICM
JEWISH FAMILY & CHILDREN'S SERVICES
KITCHEN ON THE STREET
MAGGIE’S PLACE
MISSION OF MERCY, ARIZONA
NEW LIFE CENTER
OVARIAN CANCER RESEARCH AT TGEN
PHOENIX DAY
PHOENIX RESCUE MISSION
ROSIE'S HOUSE
SAVE THE FAMILY FOUNDATION OF ARIZONA
SINGLETON MOMS
SOUTHWEST CENTER FOR HIV/AIDS
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STREETLIGHTUSA
TEACH FOR AMERICA
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TGEN, TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
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WASTE NOT

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